Welcome to Native Roots

Native Roots

South Denver

front range


2645 South Santa Fe Drive

Denver, CO 80223



Medical 18+ Recreational 21+

Our Santa Fe Denver marijuana dispensary is nestled just south of Evans Avenue on Santa Fe Drive, between Ruby Hill Park and the Gothic Theatre. The south side of Denver is a hidden gem with plenty of parks, music venues, unique restaurants, and bars. This location shines extra light on an area of Denver that is getting more and more attention from locals and visitors alike.

Native Roots Santa fe Marijuana Dispensary  location

We are Known for a quality experience and consistent product that you can rely on. At Native Roots, we’ve built our reputation on growing and selling the best weed in Colorado. Our South Denver weed shop has hired a stellar crew of budtenders who will make your experience a positive one each time. So don’t worry about not knowing everything about marijuana products or what you’re looking for. Our friendly and helpful budtenders will get to know you and what pot strain is best for you.


Monday 9am-11:50pm

Tuesday 9am-11:50pm

Wednesday 9am-11:50pm

Thursday 9am-11:50pm

Friday 9am-11:50pm

Saturday 9am-11:50pm

Sunday 9am-11:50pm


The quality of bud and selection of strains is unlike any other dispensary in the area. We offer a variety of pot products at the South Denver marijuana dispensary, like:

  • Edible marijuana products

  • Gear and accessories

  • Topical products

  • Pre-rolled joints

  • Concentrates

  • Cartridges

  • Cannasap

  • Shatter

  • Bubble

  • Flower

  • Seeds

  • Wax

Our ongoing commitment to quality weed and customer service is why we’re widely considered the best choice in South Denver for medical and residential marijuana. So whether you’re a local, a visitor, or a student, come and visit us today!


South Denver’s Top Pot Shop